Details

Autor(en) / Beteiligte

• CORCIONE, Anna
• ARDUINO, Nicoletta
• SEMENZATO, Gianpietro
• PISTOIA, Vito
• FERRETTI, Elisa
• RAFFAGHELLO, Lizzia
• RONCELLA, Silvio
• ROSSI, Davide
• FEDELI, Franco
• OTTONELLO, Luciano
• TRENTIN, Livio
• DALLEGRI, Franco

Titel

CCL19 and CXCL12 Trigger in Vitro Chemotaxis of Human Mantle Cell Lymphoma B Cells

Ist Teil von

• Clinical cancer research, 2004-02, Vol.10 (3), p.964-971

Ort / Verlag

Philadelphia, PA: American Association for Cancer Research

Erscheinungsjahr

2004

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Purpose: Few data are available in the literature on chemokine receptor expression and migratory capability of mantle cell lymphoma (MCL) B cells. Information on these issues may allow us to identify novel mechanisms of chemokine-driven tumor cell migration. Experimental Design: The research was designed to investigate: ( a ) expression of CCR1 to CCR7 and CXCR1 to CXCR5 chemokine receptors; and ( b ) chemotaxis to the respective ligands in MCL B cells and in their normal counterparts, i.e. , CD5 + B cells. Results: Malignant B cells from MCL patients and normal counterparts displayed similar chemokine receptor profiles. MCL B cells were induced to migrate by CXCL12 and CCL19, whereas normal CD5 + B cells migrated to the former, but not the latter chemokine. Overnight culture of MCL B cells and their normal counterparts with CXCL12 cross-sensitized other chemokine receptors to their ligands in some tumor samples but not in CD5 + B cells. Conclusions: CCR7 and CXCR4 ligands may play a key role in tumor cell migration and spreading in vivo . CXCL12 may additionally contribute by sensitizing MCL B cells to respond to the ligands of other chemokine receptors.