Details

Autor(en) / Beteiligte

• Farrer, Matt
• Kachergus, Jennifer
• Forno, Lysia
• Lincoln, Sarah
• Wang, Deng-Shun
• Hulihan, Mary
• Maraganore, Demetrius
• Gwinn-Hardy, Katrina
• Wszolek, Zbigniew
• Dickson, Dennis
• Langston, J. William

Titel

Comparison of kindreds with parkinsonism and α-synuclein genomic multiplications

Ist Teil von

• Annals of neurology, 2004-02, Vol.55 (2), p.174-179

Ort / Verlag

Hoboken: Wiley Subscription Services, Inc., A Wiley Company

Erscheinungsjahr

2004

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• Genomic triplication of the α‐synuclein gene recently has been associated with familial Parkinson's disease in the Spellman–Muenter kindred. Here, we present an independent family, of Swedish‐American descent, with hereditary early‐onset parkinsonism with dementia due to α‐synuclein triplication. Brain tissue available from affected individuals in both kindreds provided the opportunity to compare their clinical, pathological, and biochemical phenotypes. Of note, studies of brain mRNA and soluble protein levels demonstrate a doubling of α‐synuclein expression, consistent with molecular genetic data. Pathologically, cornu ammonis 2/3 hippocampal neuronal loss appears to be a defining feature of this form of inherited parkinsonism. The profound implications of α‐synuclein overexpression for idiopathic synucleinopathies are discussed.