FEBS letters, 1990-10, Vol.273 (1-2), p.41-45
1990
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Details
- Autor(en) / Beteiligte
- Titel
- A common motif of two adjacent phosphoserines in bovine, rabbit and human cardiac troponin I
- Ist Teil von
- FEBS letters, 1990-10, Vol.273 (1-2), p.41-45
- Ort / Verlag
- Amsterdam: Elsevier B.V
- Erscheinungsjahr
- 1990
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- From rabbit and human cardiac troponin I N-terminal mono and bisphosphorylated peptides were isolated which were obtained from Lys-C proteinase digests. Two adjacent phosphoserine residues could be localized in each phosphopeptide following further tryptic digestion. The previously published sequence of rabbit cardiac troponin I had to be corrected. Two adjacent phosphoserine residues are a common motif in the very similar sequences of bovine, rabbit and human cardiac troponin I. The N-terminal sequences are: AcADRSGGSTAG DTVPAPPPVR RRS(P)S(P) ANYRAY ATEPHAK (bovine), AcADESTDA-AG EARPAPAPVR RRSPSPANYRAY ATEPHAK (rabbit), (Ac,A,D/N,G,S,S,D/N,A,A,R) EPRPAPAPIR RRS(P)SP-NYRAY ATEPHAK (human).
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/0014-5793(90)81046-QTitel-ID: cdi_proquest_miscellaneous_80077769
- Format
- –
- Schlagworte
- Amino Acid Sequence, Amino Acids - analysis, Analytical, structural and metabolic biochemistry, Animals, Biological and medical sciences, cardiac muscle, Cardiac troponin I, Cattle, Fundamental and applied biological sciences. Psychology, Human heart, Humans, Molecular Sequence Data, Myocardium - metabolism, N-terminal sequence, Peptide Fragments - isolation & purification, Phosphorylation site, Phosphoserine, Phosphoserine - analysis, Proteins, Rabbit heart, Rabbits, Sequence Homology, Nucleic Acid, troponin, Troponin - chemistry, Troponin I, Trypsin