Details

Autor(en) / Beteiligte

• Hähnel, Jonas H.
• Lindner, Karl H.
• Schürmann, Carola
• Prengel, Andreas
• Ahnefeld, Friedrich W.

Titel

What is the optimal volume of administration for endobronchial drugs?

Ist Teil von

• The American journal of emergency medicine, 1990-11, Vol.8 (6), p.504-508

Ort / Verlag

Philadelphia, PA: Elsevier Inc

Erscheinungsjahr

1990

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• During general anesthesia, three groups of six patients each received 2 mg/kg lidocaine as a marker substance endobronchially in either 10, 5, or 3 mL distilled water, it was found that the group receiving 10 mL initially exhibited the highest lidocaine plasma concentration with a mean of 2.01 μg/mL, in comparison with 1.25 μg/mL in the 5 mL group and 0.95 μg/mL in the 3 mL group. After about 10 minutes, concentration courses were almost the same in the 10 mL and the 5 mL groups. The Pao 2 in the 10 mL group dropped initialty by approximately 40 mm Hg on average and remained low over 60 minutes. By this time the Pao 2 in the 5 mL group (initial drop 46 mm Hg) had come back to the original value ( P < .05). The 3 mL group exhibited even more favorable courses in the Pao 2 (initial drop 16 mm Hg on average). However, the lidocaine plasma concentration was at the lowest at all times in this group and, moreover, under the therapeutic level of 1.5 μg/mL with the dosage used.