Details

Autor(en) / Beteiligte

• Fang, W
• Weintraub, B C
• Dunlap, B
• Garside, P
• Pape, K A
• Jenkins, M K
• Goodnow, C C
• Mueller, D L
• Behrens, T W

Titel

Self-reactive B lymphocytes overexpressing Bcl-xL escape negative selection and are tolerized by clonal anergy and receptor editing

Ist Teil von

• Immunity (Cambridge, Mass.), 1998-07, Vol.9 (1), p.35-45

Ort / Verlag

United States

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• Self-reactive B cells Tg for both a bcl-xL death inhibitory gene and an Ig receptor recognizing hen egg lysozyme (HEL-Ig) efficiently escaped developmental arrest and deletion in mice expressing membrane-bound self-antigen (mHEL). In response to the same antigen, Tg HEL-Ig B cells not expressing bcl-xL were deleted, while cells expressing bcl-2 were arrested at the immature B stage. Bcl-xL Tg B cells escaping negative selection were anergic in both in vitro and in vivo assays and showed some evidence for receptor editing. These studies suggest that Bcl-x may have a distinct role in controlling survival at the immature stage of B cell development and demonstrate that tolerance is preserved when self-reactive B cells escape central deletion.