Details

Autor(en) / Beteiligte

• Bierer, Donald E
• Dubenko, Larisa G
• Zhang, Pingsheng
• Lu, Qing
• Imbach, Patricia A
• Garofalo, Albert W
• Phuan, Puay-Wah
• Fort, Diana M
• Litvak, Joane
• Gerber, R. Eric
• Sloan, Barbara
• Luo, Jian
• Cooper, Raymond
• Reaven, Gerald M

Titel

Antihyperglycemic Activities of Cryptolepine Analogues:  An Ethnobotanical Lead Structure Isolated from Cryptolepis sanguinolenta

Ist Teil von

• Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2754-2764

Ort / Verlag

Washington, DC: American Chemical Society

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure−bioactivity study about the cryptolepine nucleus.