Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2754-2764
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Antihyperglycemic Activities of Cryptolepine Analogues: An Ethnobotanical Lead Structure Isolated from Cryptolepis sanguinolenta
- Ist Teil von
- Journal of medicinal chemistry, 1998-07, Vol.41 (15), p.2754-2764
- Ort / Verlag
- Washington, DC: American Chemical Society
- Erscheinungsjahr
- 1998
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Cryptolepine (1) is a rare example of a natural product whose synthesis was reported prior to its isolation from nature. In the previous paper we reported the discovery of cryptolepine's antihyperglycemic properties. As part of a medicinal chemistry program designed to optimize natural product lead structures originating from our ethnobotanical and ethnomedical field research, a series of substituted and heterosubstituted cryptolepine analogues was synthesized. Antihyperglycemic activity was measured in vitro and in an NIDDM mouse model to generate the first structure−bioactivity study about the cryptolepine nucleus.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0022-2623eISSN: 1520-4804DOI: 10.1021/jm970735nTitel-ID: cdi_proquest_miscellaneous_80023375
- Format
- –
- Schlagworte
- 3T3 Cells, Adipose Tissue - cytology, Adipose Tissue - drug effects, Adipose Tissue - metabolism, Alkaloids - chemical synthesis, Alkaloids - chemistry, Alkaloids - pharmacology, Animals, Biological and medical sciences, Biological Transport - drug effects, Blood Glucose - metabolism, Diabetes Mellitus, Experimental - blood, General and cellular metabolism. Vitamins, Glucose - metabolism, Hypoglycemic Agents - chemical synthesis, Hypoglycemic Agents - chemistry, Hypoglycemic Agents - pharmacology, Indole Alkaloids, Indoles, Medical sciences, Mice, Mice, Obese, Pharmacology. Drug treatments, Plants, Medicinal - chemistry, Quinolines, Structure-Activity Relationship