Details

Autor(en) / Beteiligte

• Hecht, Frederick M
• Grant, Robert M
• Petropoulos, Christos J
• Dillon, Beth
• Chesney, Margaret A
• Tian, Huan
• Hellmann, Nicholas S
• Bandrapalli, Nirmala I
• Digilio, Laura
• Branson, Bernard
• Kahn, James O

Titel

Sexual Transmission of an HIV-1 Variant Resistant to Multiple Reverse-Transcriptase and Protease Inhibitors

Ist Teil von

• The New England journal of medicine, 1998-07, Vol.339 (5), p.307-311

Ort / Verlag

Boston, MA: Massachusetts Medical Society

Erscheinungsjahr

1998

Quelle

Electronic Journals Library

Beschreibungen/Notizen

• Combination treatments with agents that inhibit protease and reverse transcriptase of human immunodeficiency virus type 1 (HIV-1) decrease mortality and slow disease progression. 1 The development of resistance to these drugs, however, limits the benefit of such treatments. 2 , 3 There have been reports of the transmission of HIV-1 variants that are resistant to nucleoside and non-nucleoside inhibitors of reverse transcriptase. 4 – 9 The transmission of HIV-1 variants that are resistant to protease inhibitors could represent an important emerging clinical and public health problem. We report a case of transmission of an HIV-1 variant with multiple mutations that conferred resistance to both protease . . .