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Amniocentesis before 14 completed weeks as an alternative to transabdominal chorionic villus sampling: a controlled trial with infant follow-up
Prenatal diagnosis, 1998-05, Vol.18 (5), p.465-475
Nagel, Hélène T. C.
Vandenbussche, Frank P. H. A.
Keirse, Marc J. N. C.
Oepkes, Dick
Oosterwijk, Jan C.
Beverstock, Geoffrey
Kanhai, Humphrey H. H.
1998
Volltextzugriff (PDF)
Details
Autor(en) / Beteiligte
Nagel, Hélène T. C.
Vandenbussche, Frank P. H. A.
Keirse, Marc J. N. C.
Oepkes, Dick
Oosterwijk, Jan C.
Beverstock, Geoffrey
Kanhai, Humphrey H. H.
Titel
Amniocentesis before 14 completed weeks as an alternative to transabdominal chorionic villus sampling: a controlled trial with infant follow-up
Ist Teil von
Prenatal diagnosis, 1998-05, Vol.18 (5), p.465-475
Ort / Verlag
Chichester, UK: John Wiley & Sons, Ltd
Erscheinungsjahr
1998
Quelle
MEDLINE
Beschreibungen/Notizen
A (semi‐) randomized controlled study with long‐term follow‐up was conducted to compare the effects of transabdominal chorionic villus sampling and early amniocentesis on fetal mortality and child morbidity. Women requesting early prenatal diagnosis for advanced maternal age were allocated to early amniocentesis or transabdominal chorionic villus sampling either by randomization or, if they declined randomization, by their own choice. Of the 212 women who entered the study, 117 were randomized, 70 chose early amniocentesis and 25 chose transabdominal chorionic villus sampling. Overall, 130 women underwent early amniocentesis and 74 underwent transabdominal chorionic villus sampling at a median gestation of 12 weeks. Two women were excluded because of fetal death before the procedure. Mosaic karyotypes were found in 5·4 per cent of the early amniocenteses and in none of the chorionic villus samples. All unintended fetal losses occurred after early amniocentesis with a frequency of 6·2 per cent (95 per cent confidence interval: 2·7 per cent to 11·8 per cent). Talipes equinovarus was only observed after early amniocentesis with a frequency of 3·1 per cent (95 per cent confidence interval: 0·8 per cent to 7·7 per cent). We conclude that chorionic villus sampling remains the method of choice if prenatal diagnosis is needed in the first trimester of pregnancy. © 1998 John Wiley & Sons, Ltd.
Sprache
Englisch
Identifikatoren
ISSN: 0197-3851
eISSN: 1097-0223
DOI: 10.1002/(SICI)1097-0223(199805)18:5<465::AID-PD325>3.0.CO;2-#
Titel-ID: cdi_proquest_miscellaneous_79926576
Format
–
Schlagworte
Amniocentesis - adverse effects
,
Biological and medical sciences
,
Cells, Cultured
,
Chorionic Villi Sampling - adverse effects
,
chorionic villus sampling
,
Chromosome Aberrations
,
clubfoot
,
Congenital Abnormalities
,
early amniocentesis
,
Female
,
first trimester amniocentesis
,
Follow-Up Studies
,
Gestational Age
,
Gynecology. Andrology. Obstetrics
,
Humans
,
Karyotyping
,
Management. Prenatal diagnosis
,
Medical sciences
,
Mosaicism
,
Pregnancy
,
Pregnancy Outcome
,
Pregnancy. Fetus. Placenta
,
randomized controlled trial
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