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European journal of biochemistry, 1990-07, Vol.190 (3), p.445-462
Ort / Verlag
Oxford, UK: Blackwell Publishing Ltd
Erscheinungsjahr
1990
Link zum Volltext
Quelle
MEDLINE
Beschreibungen/Notizen
This chapter will serve as a mini-review of the field of IGF, presenting the most prominent biochemical and clinical aspects of IGF, in which only review articles will be cited. IGF I and II are single-chain polypeptides of about 7.5 kDa which occur in blood plasma at concentrations of 20-80 nM and at lower concentrations in most if not all tissues of the body. IGF circulating in the blood is probably produced by the liver, whereas tissue IGF is produced to a greater part locally. The significance of endocrine vs paracrine/autocrine actions is at present not clear. The expression of IGF I and, to a lesser degree, of IGF II is under the control of GH. IGF I acts as feedback inhibitor at the pituitary level of the GH release and/or GH gene transcription. IGF I can mimic most, but probably not all, effects of GH.