Details

Autor(en) / Beteiligte

• MacLean, A
• Wei, XQ
• Huang, FP
• Al-Alem, UA
• Chan, WL
• Liew, FY

Titel

Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses

Ist Teil von

• Journal of general virology, 1998-04, Vol.79 (4), p.825-830

Ort / Verlag

England: Soc General Microbiol

Erscheinungsjahr

1998

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• A MacLean, XQ Wei, FP Huang, UA Al-Alem, WL Chan and FY Liew Division of Virology, University of Glasgow, UK. Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed by gene-targeting, were significantly more susceptible to herpes simplex virus (HSV)-1 infection, displayed a delayed clearance of virus from the dorsal root ganglia (DRG) and exhibited an increase in the frequency of virus reactivation in DRG compared with similarly infected heterozygous mice. The infected iNOS-deficient mice developed enhanced Th1-type immune responses and their spleen cells produced higher concentrations of IL-12 than similarly infected heterozygous mice. This finding suggests that iNOS plays an important role in resistance against HSV-1 infection. Furthermore, nitric oxide (NO) may block the development of Th1 cells via inhibition of IL-12 synthesis and thereby play a role in immune regulation.