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Mice lacking inducible nitric-oxide synthase are more susceptible to herpes simplex virus infection despite enhanced Th1 cell responses
Ist Teil von
Journal of general virology, 1998-04, Vol.79 (4), p.825-830
Ort / Verlag
England: Soc General Microbiol
Erscheinungsjahr
1998
Quelle
Free E-Journal (出版社公開部分のみ)
Beschreibungen/Notizen
A MacLean, XQ Wei, FP Huang, UA Al-Alem, WL Chan and FY Liew
Division of Virology, University of Glasgow, UK.
Mice deficient in the inducible nitric-oxide synthase (iNOS), constructed
by gene-targeting, were significantly more susceptible to herpes simplex
virus (HSV)-1 infection, displayed a delayed clearance of virus from the
dorsal root ganglia (DRG) and exhibited an increase in the frequency of
virus reactivation in DRG compared with similarly infected heterozygous
mice. The infected iNOS-deficient mice developed enhanced Th1-type immune
responses and their spleen cells produced higher concentrations of IL-12
than similarly infected heterozygous mice. This finding suggests that iNOS
plays an important role in resistance against HSV-1 infection. Furthermore,
nitric oxide (NO) may block the development of Th1 cells via inhibition of
IL-12 synthesis and thereby play a role in immune regulation.