FEBS letters, 1998-03, Vol.425 (2), p.213-216
1998
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Details
- Autor(en) / Beteiligte
- Titel
- Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain
- Ist Teil von
- FEBS letters, 1998-03, Vol.425 (2), p.213-216
- Ort / Verlag
- England: Elsevier B.V
- Erscheinungsjahr
- 1998
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H 2O 2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H 2O 2 generation. This H 2O 2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O 2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0014-5793eISSN: 1873-3468DOI: 10.1016/S0014-5793(98)00231-2Titel-ID: cdi_proquest_miscellaneous_79811154
- Format
- –
- Schlagworte
- Adenosine Triphosphate - metabolism, Adenosine Triphosphate - pharmacology, Animals, Calcium - metabolism, Calcium - pharmacology, Carrier Proteins - metabolism, Coenzyme Q, Electron Transport, Free radical, Hydrogen Peroxide - metabolism, Ion Channels, Linoleic Acid - metabolism, Membrane Potentials - drug effects, Membrane Proteins - metabolism, Mitochondria - drug effects, Mitochondria - metabolism, Mitochondria, Liver - drug effects, Mitochondria, Liver - metabolism, Mitochondrial Proteins, Mitochondrion, Plant uncoupling mitochondrial protein, Rats, Reactive oxygen species, Reactive Oxygen Species - metabolism, Serum Albumin, Bovine - metabolism, Serum Albumin, Bovine - pharmacology, Solanum tuberosum - metabolism, Uncoupling Protein 1