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Activation of the potato plant uncoupling mitochondrial protein inhibits reactive oxygen species generation by the respiratory chain
Ist Teil von
FEBS letters, 1998-03, Vol.425 (2), p.213-216
Ort / Verlag
England: Elsevier B.V
Erscheinungsjahr
1998
Quelle
Wiley Online Library - AutoHoldings Journals
Beschreibungen/Notizen
A variety of plant tissues contain an uncoupling mitochondrial protein (PUMP), recently described and characterized by our group. In this study we show that the inhibition of PUMP activity in potato tuber mitochondria significantly increases mitochondrial H
2O
2 generation, while PUMP substrates, such as linoleic acid, reduce mitochondrial H
2O
2 generation. This H
2O
2 generation occurred mainly by the dismutation of superoxide radicals formed through monoelectronic reduction of O
2 by semiquinone forms of coenzyme Q. The results presented suggest that protection against mitochondrial oxidative stress may be a physiological role of PUMP.