Muscle & nerve, 1990-05, Vol.13 (5), p.407-413
1990
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Details
- Autor(en) / Beteiligte
- Titel
- A myasthenia gravis plasma immunoglobulin reduces miniature endplate potentials at human endplates in vitro
- Ist Teil von
- Muscle & nerve, 1990-05, Vol.13 (5), p.407-413
- Ort / Verlag
- Hoboken: Wiley Subscription Services, Inc., A Wiley Company
- Erscheinungsjahr
- 1990
- Quelle
- Wiley Online Library - AutoHoldings Journals
- Beschreibungen/Notizen
- A particular myasthenia gravis (MG) plasma Ig has previously been shown to block a single α‐bungarotoxin (α‐BuTX) binding site on embryonic rat muscle acetylcholine receptor (AChR). We have investigated its effect on embryonic/denervated and adult human AChR both in extracts and in situ. Plasma Ig blocked 125I‐α‐BuTx binding by greater than 85% to the AChR extracted from denervated muscle, but only by 55% to AChR extracted from normal human muscle. Incubation of intact human muscle fibers with the plasma Ig reduced 125I‐α‐BuTx binding to the endplate AChRs by 63%, and substantially decreased the amplitude of miniature endplate potentials. We conclude that anti‐α‐BuTx site antibodies, when present, can be important in the pathophysiology of the disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0148-639XeISSN: 1097-4598DOI: 10.1002/mus.880130507Titel-ID: cdi_proquest_miscellaneous_79794235
- Format
- –
- Schlagworte
- acetylcholine receptor, Biological and medical sciences, Biopsy, Bungarotoxins - adverse effects, Bungarotoxins - antagonists & inhibitors, Bungarotoxins - immunology, Diseases of striated muscles. Neuromuscular diseases, Evoked Potentials - drug effects, Evoked Potentials - physiology, human muscle, human muscle, miniature endplate potentials, Humans, Immunoglobulins - pharmacology, Immunoglobulins - physiology, In Vitro Techniques, Medical sciences, miniature endplate potentials, Motor Endplate - drug effects, Motor Endplate - immunology, Motor Endplate - physiology, Muscles - pathology, myasthenia, Myasthenia Gravis - blood, Myasthenia Gravis - etiology, Myasthenia Gravis - immunology, Neurology, Neuromuscular Junction - drug effects, Receptors, Cholinergic - drug effects, Receptors, Cholinergic - immunology, α-bungarotoxin site