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Undulin, an extracellular matrix glycoprotein associated with collagen fibrils
Ist Teil von
The Journal of biological chemistry, 1990-05, Vol.265 (15), p.8823-8832
Ort / Verlag
Bethesda, MD: American Society for Biochemistry and Molecular Biology
Erscheinungsjahr
1990
Quelle
MEDLINE
Beschreibungen/Notizen
Undulin, a novel noncollagenous extracellular matrix protein, was isolated from skin and placenta. In polyacrylamide gels
most of the unreduced protein migrates with Mr above 1,000,000 yielding bands A (Mr 270,000), B1 (Mr 190,000), and B2 (Mr
180,000) after reduction. Undulin is biochemically and immunochemically distinct from other previously characterized large
matrix glycoproteins. Immunoblotting using monoclonal antibodies suggests that bands A and B are closely related. Electron
microscopy reveals undulin as structures consisting of an approximately 80-nm-long-tail with a nodule on one end and with
one or two shorter arms on the other. Ultrastructurally immunolabeled undulin is found mainly between densely packed mature
collagen fibrils. Indirect immunofluorescence shows bundles of uniform wavy fibers in dense connective tissues superimposable
on a subpopulation of type I collagen structures. This suggests that undulin serves a specific yet unknown function in the
supramolecular organization of collagen fibrils in soft tissues.