Details

Autor(en) / Beteiligte

• Angel, Jonathan B.
• Kumar, Ashok
• Parato, Karl
• Filion, Lionel G.
• Diaz-Mitoma, Francisco
• Daftarian, Pirouz
• Pham, Ba'
• Sun, Eugene
• Leonard, John M.
• Cameron, D. William

Titel

Improvement in Cell-Mediated Immune Function during Potent Anti-Human Immunodeficiency Virus Therapy with Ritonavir plus Saquinavir

Ist Teil von

• The Journal of infectious diseases, 1998-04, Vol.177 (4), p.898-904

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1998

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Inhibiting human immunodeficiency virus (HIV) replication with potent antiretroviral therapy may result in improved immune function, and this may lead to favorable outcomes, independent of changes in CD4+ lymphocyte count. The effect of combination protease inhibitor therapy (ritonavir plus saquinavir) on functional measures of cell-mediated immunity in 41 HIV-infected patients from one center of a multicenter trial was investigated. After 24 weeks, median plasma virus load decreased from 4.74 log10 copies/mL to below the detection limit of the assay (2.30 log10), and mean CD4+ lymphocyte count increased from 284 cells/mL to 413 cells/mL. Proliferative responses to phytohemagglutinin developed in 21 of 34 patients in whom responses were absent at baseline. Increases were observed in interleukin-2, -12, and -10 production and in the expression of CD28 on CD8+ lymphocytes. Initiation of potent anti-HIV therapy results in a degree of immune restoration, suggesting that HIV-induced immune suppression is a dynamic and potentially reversible process.