Nature (London), 1990-05, Vol.345 (6270), p.71-74
1990
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- Autor(en) / Beteiligte
- Titel
- Association of CD2 and CD45 on human T lymphocytes
- Ist Teil von
- Nature (London), 1990-05, Vol.345 (6270), p.71-74
- Ort / Verlag
- London: Nature Publishing
- Erscheinungsjahr
- 1990
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- At least two membrane receptors have been defined through which human T lymphocytes can be induced to proliferate and differentiate, namely the CD3-Ti antigen receptor complex and the CD2 molecule. Monoclonal antibodies directed at either CD2 or CD3 induce intracellular second messenger production and subsequent protein phosphorylation. On most human non-B lymphocytes, CD3-Ti and CD2 are coexpressed and seem to be functionally interrelated. But there are minor subpopulations in which these receptor systems can transduce signals despite a mutually exclusive expression, indicating that CD3-Ti and CD2 can act independently of each other. This view is supported by the finding that most monoclonal antibodies directed at the CD45 molecules are strongly co-mitogenic with CD2 but not CD3 monoclonal antibodies. As the intracytoplasmic domains of CD45 have tyrosine phosphatase activity these functional effects could be explained by a physical association between CD2 and CD45. Using chemical crosslinking techniques, we now show that CD45 is linked to CD2 on the surface of human T lymphocytes.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/345071a0Titel-ID: cdi_proquest_miscellaneous_79740721
- Format
- –
- Schlagworte
- Antibodies, Monoclonal - pharmacology, Antigens, Antigens, CD - immunology, Antigens, Differentiation - immunology, Antigens, Differentiation, T-Lymphocyte - immunology, Biochemistry, Biological and medical sciences, CD2 Antigens, CD3 antigen, CD3 Complex, CD45 antigen, Cellular biology, Cross-Linking Reagents - pharmacology, Crosslinking, Domains, Enzyme-Linked Immunosorbent Assay, Experiments, Fundamental and applied biological sciences. Psychology, Fundamental immunology, Histocompatibility Antigens - immunology, Histocompatibility Antigens Class I - immunology, Humans, Immunobiology, Immunoglobulins, Immunosorbent Techniques, Leukocyte Common Antigens, Lymphocytes, Lymphocytes B, Lymphocytes T, Lymphoid cells: ontogeny, maturation, markers, receptors, circulation and recirculation, Molecular Weight, Molecules, Monoclonal antibodies, Organic chemistry, Peptide Fragments, Peptides, Phosphatase, Phosphoprotein Phosphatases - metabolism, Phosphoproteins - metabolism, Phosphorylation, Protein Tyrosine Phosphatases, Protein-tyrosine-phosphatase, Proteins, Receptors, Receptors, Antigen, T-Cell - immunology, Receptors, Immunologic - immunology, Second Messenger Systems, Serine Endopeptidases, Subpopulations, Succinimides - pharmacology, T-Lymphocytes - immunology, Tyrosine