Details

Autor(en) / Beteiligte

• Kitamura, Noboru
• Nishino, Naoki
• Hashimoto, Takeshi
• Kajimoto, Yasuo
• Shirai, Yutaka
• Murakami, Naoya
• Yang, Chang-Qing
• Lin, Xian-Hao
• Yamamoto, Hideo
• Nakai, Takashi
• Mita, Tatsuo
• Komure, Osamu
• Shirakawa, Osamu
• Nakai, Hisao

Titel

Asymmetrical changes in the fodrin α subunit in the superior temporal cortices in schizophrenia

Ist Teil von

• Biological psychiatry (1969), 1998-02, Vol.43 (4), p.254-262

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1998

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We examined possible abnormalities in neural structural proteins that may underlie morphometric changes reported in the left superior temporal cortices (Brodmann's area 22) of schizophrenics. Particulate proteins of the superior temporal cortices taken at autopsy from 11 schizophrenic and 9 control brains were fractionated by gel electrophoresis. Target proteins, identified by reading their amino acid sequences, were immunoquantified using the specific antibody. Amino acid sequences of the 150-kDa proteins on sodium dodecyl sulfate/polyacrylamide gel electrophoresis, which were significantly increased on the left side of schizophrenic superior temporal cortices, revealed that they were proteolytic fragments of the α subunit of fodrin, a major cytoskeletal protein underlying the plasma membrane. Immunoquantification using the specific antibodies against α and β subunits of fodrin indicated that there exist concomitant decreases in the full-length 240-kDa form and increases in the 150-kDa, form of α fodrin with no changes of the 235-kDa form of β-fodrin in the left superior temporal cortices of the schizophrenic brains. The findings may be a possible molecular basis for linking morphometric changes to neurochemical pathophysiology in schizophrenia.