Details

Autor(en) / Beteiligte

• Shaulsky, G
• Fuller, D
• Loomis, W F

Titel

A cAMP-phosphodiesterase controls PKA-dependent differentiation

Ist Teil von

• Development (Cambridge), 1998-02, Vol.125 (4), p.691-699

Ort / Verlag

England: The Company of Biologists Limited

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• A cAMP-specific phosphodiesterase was found that is stimulated by binding to the regulatory subunit of cAMP-dependent protein kinase, PKA-R, from either Dictyostelium or mammals. The phosphodiesterase is encoded by the regA gene of Dictyostelium, which was recovered in a mutant screen for strains that sporulate in the absence of signals from prestalk cells. The sequence of RegA predicts that it will function as a member of a two-component system. Genetic analyses indicate that inhibition of the phosphodiesterase results in an increase in the activity of PKA, which acts at a check point for terminal differentiation. Conserved components known to affect memory, learning and differentiation in flies and vertebrates suggest that a similar circuitry functions in higher eukaryotes.