Details

Autor(en) / Beteiligte

• KANOLD, J
• BERGER, M
• MALPUECH, G
• DEMEOCQ, F
• HALLE, P
• RAPATEL, C
• SCHOEPFER, C
• DE LUMLEY, L
• VANNIER, J.-P
• LUTZ, P
• PLANTAZ, D
• STEPHAN, J. L

Titel

Kinetics of hematopoietic progenitor cell release induced by G-CSF-alone in children with solid tumors and leukemias

Ist Teil von

• Bone marrow transplantation (Basingstoke), 1998, Vol.21 (1), p.59-63

Ort / Verlag

Basingstoke: Nature Publishing Group

Erscheinungsjahr

1998

Quelle

MEDLINE

Beschreibungen/Notizen

• The kinetics of peripheral blood progenitor cell (PBPC) release induced by G-CSF-alone at 10 microg/kg/day were monitored daily in 42 children with solid tumors and leukemias. Median 16- and 27-fold enrichment of circulating CD34+ cells and granulocyte-macrophage colony-forming units (CFU-GM) was noted with peak values occurring after the 4th or the 5th G-CSF dose. Individual values of PBCD34+ cell levels in patients with solid tumors were not significantly different after the 4th and after the 5th dose. The day-of-collection PBCD34+ cell concentration was related to the harvested CD34+ cell (P = 0.0001) and CFU-GM numbers (P = 0.0001). No correlations were found between PBPC enrichment and either patient age, body weight, diagnosis or pre-mobilization treatment duration. The median numbers of 1.1 x 10(6) CD34+ cells/kg and 28.1 x 10(4) CFU-GM/kg were derived from one patient's blood volume processed. Nineteen patients received G-CSF-alone primed grafts and had successful engraftment. Our data indicate that in 88% of children a single standard leukapheresis is sufficient to obtain a minimum graft (2 x 10(6) CD34+ cell and/or 10 x 10(4) CGU-GM per kg) whether undertaken after the 4th dose of G-CSF or the 5th.