Science (American Association for the Advancement of Science), 1990-03, Vol.247 (4947), p.1216-1219
1990
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Control of the Interferon-Induced 68-Kilodalton Protein Kinase by the HIV-1 tat Gene Product
- Ist Teil von
- Science (American Association for the Advancement of Science), 1990-03, Vol.247 (4947), p.1216-1219
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1990
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The tat-responsive region (TAR) of the human immunodeficiency virus-1 (HIV-1) exhibits a trans-inhibitory effect on translation in vitro by activating the interferon-induced 68-kilodalton protein kinase (p68 kinase). Productive infection by HIV-1 was shown to result in a significant decrease in the amount of cellular p68 kinase. The steady-state amount of p68 kinase was also reduced in interferon-treated HeLa cell lines stably expressing tat, as compared to the amount of the kinase in interferon-treated control HeLa cells. Thus, the potential translational inhibitory effects of the TAR RNA region mediated by activation of p68 kinase may be downregulated by tat during productive HIV-1 infection.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.2180064Titel-ID: cdi_proquest_miscellaneous_79678997
- Format
- –
- Schlagworte
- 2',5'-Oligoadenylate Synthetase - genetics, Acquired immune deficiency syndrome, Actins, AIDS, AIDS/HIV, Analysis, Biological and medical sciences, Cell extracts, Cell lines, Down-Regulation, Enzyme Induction, Fundamental and applied biological sciences. Psychology, Gene Expression Regulation, Enzymologic, Gene Products, tat - physiology, Genes, tat, Genes, Viral, Genetic aspects, Genetics, HeLa Cells, HIV, HIV (Viruses), HIV 1, HIV infection, HIV infections, HIV-1 - genetics, Human immunodeficiency virus 1, Humans, Immunoblotting, Immunosorbent Techniques, Infections, Interferon, Interferon Type I - pharmacology, Interferons, Medical research, Messenger RNA, Microbiology, Molecular Weight, Physiological aspects, Protein kinases, Protein Kinases - biosynthesis, Protein Kinases - genetics, Protein research, Proteins, Reproduction, RNA, tat Gene Products, Human Immunodeficiency Virus, Trans-Activators - physiology, Transfection, Virology, Virus replication, Xenopus