The Journal of Antibiotics, 1990/02/25, Vol.43(2), pp.129-134
1990
Details
- Autor(en) / Beteiligte
- Titel
- RESORTHIOMYCIN, A NOVEL ANTITUMOR ANTIBIOTIC: I. TAXONOMY, ISOLATION AND BIOLOGICAL ACTIVITY
- Ist Teil von
- The Journal of Antibiotics, 1990/02/25, Vol.43(2), pp.129-134
- Ort / Verlag
- Tokyo: JAPAN ANTIBIOTICS RESEARCH ASSOCIATION
- Erscheinungsjahr
- 1990
- Link zum Volltext
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- Resorthiomycin, a novel antitumor antibiotic, was isolated from the fermentation broth of a strain of Streptomyces collinus by ethyl acetate extraction, silica gel chromatography and HPLC. Resorthiomycin exhibited an in vitro cytotoxic activity against mouse leukemia L5178Y cells (IC50, 15.5 μg/ml) and also inhibited the clonogenic activity of a multidrug-resistant mutant of human hepatoma PLC/PRF/5 cells to a greater extent than that of the parental cells. On the other hand, this antibiotic does not possess any antibacterial or antifungal activity.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0021-8820eISSN: 1881-1469DOI: 10.7164/antibiotics.43.129Titel-ID: cdi_proquest_miscellaneous_79668350
- Format
- –
- Schlagworte
- Animals, Antibiotics, Antineoplastic - isolation & purification, antitumor antibiotics, Biological and medical sciences, Carcinoma, Hepatocellular, Cell Line - drug effects, Chromatography, High Pressure Liquid, General aspects, hepatoma, Humans, leukemia, Leukemia L5178, Liver Neoplasms, Medical sciences, Mice, Neuropharmacology, Pharmacology. Drug treatments, Resorcinols - isolation & purification, Resorcinols - pharmacology, resorthiomycin, Streptomyces - analysis, Streptomyces cyaneus