Details

Autor(en) / Beteiligte

• Slavis, Scott A.
• Scholz, John N.
• Hewitt, Charles W.
• Black, Kirby S.
• Campbell, Richard S.
• Patel, Mayuri
• Zimmerman, James
• Peake, Meredith L.
• Martin, Donald C.

Titel

The Effects of Testicular Trauma on Fertility in the Lewis Rat and Comparisons to Isoimmunized Recipients of Syngeneic Sperm

Ist Teil von

• The Journal of urology, 1990-03, Vol.143 (3), p.638-641

Ort / Verlag

United States: Elsevier Inc

Erscheinungsjahr

1990

Quelle

MEDLINE

Beschreibungen/Notizen

• Adult male Lewis (LEW) rats were used to investigate the effects of unilateral testicular trauma on fertility. Comparisons were made between normal and experimental rats immunized with syngeneic sperm in Complete Freund’s Adjuvant (CFA). Matings within the three groups yielded offspring to all normal males, no offspring to the immunized rats, and 27% (3/11) fertility in the trauma group (p < 0.001). The contralateral testis demonstrated decreased volumes, various degrees of aspermatogenesis and smaller seminiferous tubular diameters, in both the trauma and immunized groups compared to the controls. Similar histopathologic findings of chronic granulomatous inflammation within contralateral testes in both the trauma and immunized groups suggested a common immune etiology for infertility via possible disruption of the blood-testis barrier. (J. Urol., 143: 638-641, 1990)