Brain research, 1990-01, Vol.506 (2), p.291-293
1990
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Details
- Autor(en) / Beteiligte
- Titel
- Gangliosides improve synaptic transmission in dentate gyrus of hippocampal rat slices
- Ist Teil von
- Brain research, 1990-01, Vol.506 (2), p.291-293
- Ort / Verlag
- London: Elsevier B.V
- Erscheinungsjahr
- 1990
- Quelle
- Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
- Beschreibungen/Notizen
- The effect of perfusion with gangliosides (1 × 10 −6M) on the response evoked in the granule cell layer of dentate gyrus by stimulation of perforant path in hippocampal rat slices was studied. Gangliosides induced both a decrease in the frequency threshold of stimulation necessary to generate long-term potentiation (LTP) and greater potentiation than under control conditions. It is proposed that gangliosides improve the mechanisms responsible for synaptic plasticity which generate LTP.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0006-8993eISSN: 1872-6240DOI: 10.1016/0006-8993(90)91264-HTitel-ID: cdi_proquest_miscellaneous_79612887
- Format
- –
- Schlagworte
- Action Potentials - drug effects, Animals, Biological and medical sciences, Central nervous system, Dentate gyrus, Electrophysiology, Fundamental and applied biological sciences. Psychology, Ganglioside, Gangliosides - pharmacology, Gangliosides - physiology, Hippocampus - drug effects, Hippocampus - physiology, In Vitro Techniques, Long-term potentiation, Male, Neuronal Plasticity - drug effects, Perforant path, Rats, Slice, Synaptic plasticity, Vertebrates: nervous system and sense organs