Details

Autor(en) / Beteiligte

• Becker, Kevin G.
• Lee, Insong J.
• Nagle, James W.
• Canning, Rachel D.
• Gado, Ameer M.
• Torres, Rosarelis
• Polymeropoulos, Mihael H.
• Massa, Paul T.
• Biddison, William E.
• Drew, Paul D.

Titel

C2H2‐171 : A novel human cDNA representing a developmentally regulated poz domain/zinc finger protein preferentially expressed in brain

Ist Teil von

• International journal of developmental neuroscience, 1997-11, Vol.15 (7), p.891-899

Ort / Verlag

United States

Erscheinungsjahr

1997

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• We describe a novel human zinc finger cNDA, C2H2‐171. This cDNA represents an mRNA which encodes a protein of 484 amino acids and a calculated molecular weight of 54 kD. Four zinc finger‐like domains are found in the C‐terminal end of the protein. At the N‐terminus, C2H2‐171 contains a POZ/tramtrack‐like domain similar to that found in the tumor associated zinc finger proteins LAZ‐3/BCL‐6 and PLZ‐F, as well as in non‐zinc finger proteins. C2H2‐171 RNA is preferentially expressed in the brain, and increases during the course of murine development, with maximal expression in the adult. C2H2‐171 RNA is differentially expressed in brain regions, with the highest level of expression in the cerebellum. C2H2‐171 RNA was expressed at high levels in primary cerebellar granule cell neurons compared to astrocytes. The gene encoding C2H2‐171 is highly conserved in vertebrates, and maps to the terminus of human chromosome 1 (1q44‐ter). This chromosomal location is associated with a number of cytogenetic aberrations including those involving brain developmental anomalies and tumorigenesis. These data suggest that C2H2‐171 may play an important role in vertebrate brain development and function.