Chemical and Pharmaceutical Bulletin, 1989/05/25, Vol.37(5), pp.1401-1403
1989
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Details
- Autor(en) / Beteiligte
- Titel
- Effect of pH Small Inorganic Ions on Binding of Sulfadimethoxine and Sulfaphenazole to Human Serum Albumin Measured by Circular Dichroism
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 1989/05/25, Vol.37(5), pp.1401-1403
- Ort / Verlag
- Tokyo: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 1989
- Quelle
- Free E-Journal (出版社公開部分のみ）
- Beschreibungen/Notizen
- The binding of sulfadimethoxine and sulfaphenazole to human serum albumin (HSA) has been shown by circular dichroism measurements to be dependent on the N-B transition. The secondary drug binding sites were found to be optically active in the B conformation form in HSA but optically inactive in the N form. Moreover, the drug-HSA interaction in Tris-HCl buffer seems to be more sensitive to the conformational change in HSA, compared with that in the phosphate buffer.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.37.1401Titel-ID: cdi_proquest_miscellaneous_79496354
- Format
- –
- Schlagworte
- Biological and medical sciences, Circular Dichroism, circular dichrosim, conformational change, Fundamental and applied biological sciences. Psychology, human serum albumin, Humans, Hydrogen-Ion Concentration, induced ellipticity, Interactions. Associations, Intermolecular phenomena, microcalorimetry, Molecular biophysics, N-B transition, Protein Binding, Serum Albumin - metabolism, Spectrophotometry, Ultraviolet, Sulfadimethoxine - blood, Sulfaphenazole - blood