Details

Autor(en) / Beteiligte

• Borchhardt, Kyra
• Haas, Martin
• Yilmaz, Nilgün
• Oberbauer, Rainer
• Schmidt, Alice
• Barnas, Ursula
• Mayer, Gert

Titel

Low dose angiotensin converting enzyme inhibition and glomerular permselectivity in renal transplant recipients

Ist Teil von

• Kidney international, 1997-12, Vol.52 (6), p.1622-1625

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1997

Link zum Volltext

Quelle

Free E-Journal (出版社公開部分のみ）

Beschreibungen/Notizen

• Low dose angiotensin converting enzyme inibition and glomerular permselectivity in renal transplant recipients. In this study, we determined the fractional clearance of neutral polydisperse dextrans (ΘD) and monodisperse dextran sulfate (ΘDS) to describe glomerular size and charge selectivity in 25 renal transplant recipients with proteinuria. Thirteen were treated with low dose lisinopril for six months (group 1) and 12 patients without ACE inhibitor therapy formed group 2. Mean arterial blood pressure was stable (group 1, 112 ± 4; group 2, 109 ± 2mm Hg at baseline and after 6 months) whereas creatinine clearance, glomerular filtration rate and renal plasma flow decreased nonsignificantly but were comparable at any time. Lisinopril treatment lowered filtration fraction (22 ± 2 vs. 19 ± 2%, P = 0.07) whereas no change was seen in group 2 (20 ± 2%). The fractional protein excretion (mg urinary protein per day/ml creatinine clearance per day) was stable in group 1, but significantly increased in group 2. The same pattern was found for ΘD larger than 56 Å. ΘDS was stable and consistently elevated in both groups at any time. We conclude that low dose ACE inhibitor treatment in proteinuric renal transplant recipients stabilizes glomerular size selectivity independently of its systemic hemodynamic effects.