Details

Autor(en) / Beteiligte

• Kulkosky, P.J.
• Doyle, J.S.
• Cook, V.I.
• Glazner, G.W.
• Foderaro, M.A.

Titel

Vasoactive intestinal peptide: Behavioral effects in the rat and hamster

Ist Teil von

• Pharmacology, biochemistry and behavior, 1989-10, Vol.34 (2), p.387-393

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1989

Quelle

Elsevier ScienceDirect Journals

Beschreibungen/Notizen

• The behavioral effects of intracerebroventricular (ICV) injection of the brain-gut peptide vasoactive intestinal peptide (VIP) were quantified with a behavioral sampling technique in home-caged, nondeprived, male and female albino rats and golden hamsters. ICV VIP sex-dependently decreased observed resting behavior during 1 hr after injections in both rats and hamsters at 0.1–10.0 μg. Grooming behavior was increased in hamsters, and rearing and standing behaviors were increased in rats, sex-dependently at VIP doses that decreased resting. Drinking behavior was suppressed in rats by VIP at 10.0 μg. Intraperitoneal (IP) VIP (100.0 μg/kg) increased 5% ethanol intake and decreased eating behavior in fluid-deprived male rats. The increase in ethanol intake produced by IP VIP was prevented by IP cholecystokinin octapeptide (CCK, 4.0 μg/kg). VIP potently controls resting and ingestive behaviors, suggesting a role for this neuropeptide, along with CCK, in the feedback regulation of rodent behavior.