Details

Autor(en) / Beteiligte

• MATSUDA, Hideaki
• DAI, Yue
• IDO, Yasuko
• YOSHIKAWA, Masayuki
• KUBO, Michinori

Titel

Studies on Kochiae Fructus IV. Anti-Allergic Effects of 70% Ethanol Extract and Its Component, Momordin Ic from Dried Fruits of Kochia scoparia L

Ist Teil von

• Biological and Pharmaceutical Bulletin, 1997/11/15, Vol.20(11), pp.1165-1170

Ort / Verlag

Tokyo: The Pharmaceutical Society of Japan

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• The 70% ethanol extract (KS-ext) from Kochiae Fructus (dried fruits of Kochia scoparia L.) has been screened for activity in experimental models of type I-IV allergy. In type I allergic models, KS-ext at doses of 200 and 500 mg/kg, p.o. exhibited an inhibitory effect on 48-h homologous passive cutaneous anaphylaxis (PCA) in rats, which is related to IgE, and 1.5-h heterologous PCA in mice, which is related to IgG. In a type III allergic model, KS-ext showed an inhibitory effect on direct passive arthus reaction (DPAR) in rats, while it had no inhibitory effect on reversed cutaneous anaphylaxis (RCA) in a type II allergic model. Furthermore, in a type IV allergic model, KS-ext had an inhibitory effect on the effector phase in picryl chloride-induced contact dermatitis (PC-CD). Also, its anti-pruritogenic component, momordin Ic (oleanane saponin) exhibited inhibitory effects on 48-h homologous PCA and PC-CD.These results indicate that Kochiae Fructus not only inhibits humoral immunity but also influences cellular immunity, and should be recognized as a material for anti-allergic reactions. Also, the mode of its anti-pruritogenic activity may be mediated by anti-allergic action, and its active component may be partially attributed to momordin Ic.