Details

Autor(en) / Beteiligte

• LJUNGGREN, K
• CHIODI, F
• BROLIDEN, P.-A
• ALBERT, J
• NORKRANS, G
• HAGBERG, L
• JONDAL, M
• FENYO, E.-M

Titel

HIV-1-specific antibodies in cerebrospinal fluid mediate cellular cytotoxicity and neutralization

Ist Teil von

• AIDS research and human retroviruses, 1989-12, Vol.5 (6), p.629-638

Ort / Verlag

Larchmont, NY: Liebert

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• Antibodies mediating HIV-1-specific cellular cytotoxicity (ADCC) and virus neutralizing activity were detected in the cerebrospinal fluid (CSF) and, as previously reported, in sera of subjects with varying severity of HIV-1 infection, including patients with or without neurologic or psychiatric symptoms. ADCC-mediating antibodies against target cells infected with the HTLV-IIIB strain of HIV-1 were less frequently present in CSF than in sera, 32 and 60%, respectively. The frequency of ADCC-positive CSF was comparable for the different clinical stages of the disease and was apparently not influenced by the presence or absence of neurologic/psychiatric symptoms. Virus-neutralizing activity was tested against HTLV-IIIB and one CSF-derived viral isolate. Serum antibodies neutralized HTLV-IIIB more frequently than the CSF isolate, 53 and 35%, respectively. In contrast, only three (7%) of the CSF specimens contained neutralizing activity to the CSF-derived isolate and none to HTLV-IIIB. Despite an intact blood-brain barrier in many subjects, the serum/CSF ratios of ADCC or neutralizing antibodies were lower than normally expected. This indicates that both ADCC-mediating and virus neutralizing antibodies may be intrathecally synthesized. Whether these antibodies are protective against or contribute to the histopathologic changes in the brain is not known at present.