Details

Autor(en) / Beteiligte

• Neva, Franklin A.
• Ponce, Carlos
• Ponce, Elisa
• Kreutzer, Richard
• Modabber, Farrokh
• Olliaro, Piero

Titel

Non-ulcerative cutaneous leishmaniasis in Honduras fails to respond to topical paromomycin

Ist Teil von

• Transactions of the Royal Society of Tropical Medicine and Hygiene, 1997-07, Vol.91 (4), p.473-475

Ort / Verlag

Oxford: Elsevier Ltd

Erscheinungsjahr

1997

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• A double-‘blind’, placebo-controlled trial of topical therapy with 15% paromomycin (aminosidine) and 10% urea in white paraffin was carried out on 53 patients with non-ulcerating cutaneous leishmaniasis in Honduras. Although the treatment was not effective, several unexpected findings emerged from the trial. Leishmania mexicana was found to be the cause of many of the skin lesions in one of the 2 study sites. These lesions were clinically indistinguishable from those caused by L. chagasi, the aetiologic agent previously found for this form of leishmaniasis. This is the first documented report of L. mexicana in Honduras.