Chemical and Pharmaceutical Bulletin, 1989/09/25, Vol.37(9), pp.2456-2458
1989
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Details
- Autor(en) / Beteiligte
- Titel
- Application of Ion-Pair High Performance Liquid Chromatography for Analysis of Hyoscyamine and Scopolamine in Solanaceous Crude Drugs
- Ist Teil von
- Chemical and Pharmaceutical Bulletin, 1989/09/25, Vol.37(9), pp.2456-2458
- Ort / Verlag
- Tokyo: The Pharmaceutical Society of Japan
- Erscheinungsjahr
- 1989
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- A new ion-pair high-performance liquid chromatographic method for the analysis of hyoscyamine and scopolamine in various kinds of crude drugs derived from solanaceous plants was evaluated using sodium dodecyl sulfate as a counter ion. A reversed-phase chromatographic system consisting of a chemically bonded ODS silica gel column with phosphate buffer (pH 2.5)-acetonitrile (65 : 35) containing 17.5mM sodium dodecyl sulfate as the mobile phase was used. Hyoscyamine and scopolamine in crude drugs derived from Scopolia, Atropa, Hyoscyamus and Datura species were separated from other compounds in the crude drugs and determined within 20 min after direct injection of the solution extracted with the mobile phase. The results for various kinds of samples are presented.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0009-2363eISSN: 1347-5223DOI: 10.1248/cpb.37.2456Titel-ID: cdi_proquest_miscellaneous_79414013
- Format
- –
- Schlagworte
- Analysis of complex biological substances, Analytical, structural and metabolic biochemistry, Atropa belladonna, atropine, Atropine - analysis, Biological and medical sciences, Chromatography, High Pressure Liquid, Datura metel, Fundamental and applied biological sciences. Psychology, hyoscyamine, Hyoscyamus niger, ion-pair high-performance liquid chromatography, Plants and fungi, Plants, Medicinal - analysis, scopolamine, Scopolamine - analysis, Scopolia japonica