Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5339), p.876-878
1997
Volltextzugriff (PDF)
Details
- Autor(en) / Beteiligte
- Titel
- Transgenic Knockout Mice with Exclusively Human Sickle Hemoglobin and Sickle Cell Disease
- Ist Teil von
- Science (American Association for the Advancement of Science), 1997-10, Vol.278 (5339), p.876-878
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1997
- Quelle
- American Association for the Advancement of Science
- Beschreibungen/Notizen
- To create mice expressing exclusively human sickle hemoglobin (HbS), transgenic mice expressing human α-, γ-, and $\beta^S$-globin were generated and bred with knockout mice that had deletions of the murine α- and β-globin genes. These sickle cell mice have the major features (irreversibly sickled red cells, anemia, multiorgan pathology) found in humans with sickle cell disease and, as such, represent a useful in vivo system to accelerate the development of improved therapies for this common genetic disease.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.278.5339.876Titel-ID: cdi_proquest_miscellaneous_79370588
- Format
- –
- Schlagworte
- Adults, Anemia, Sickle Cell - genetics, Anemia, Sickle Cell - pathology, Anemias. Hemoglobinopathies, Animals, Biological and medical sciences, Disease Models, Animal, Diseases of red blood cells, Erythrocytes, Female, Genetically modified mice, Genetics, Globins - genetics, Hematologic and hematopoietic diseases, Hemoglobin, Hemoglobin, Sickle - genetics, Hemoglobins, Hepatocytes, Humans, Kupffer cells, Male, Medical sciences, Mice, Mice, Inbred C57BL, Mice, Knockout, Mice, Transgenic, Neutrophils, Rodents, Sickle cell anemia, Sickle cell disease, Sickles, Transgenic animals