Details

Autor(en) / Beteiligte

• Locher, Christopher P.
• Blackbourn, David J.
• Barnett, Susan W.
• Murthy, Krishna K.
• Cobb, Elizabeth K.
• Rouse, Scott
• Greco, Giampaolo
• Reyes-Terán, Gustavo
• Brasky, Kathleen M.
• Carey, Kenneth D.
• Levy, Jay A.

Titel

Superinfection with Human Immunodeficiency Virus Type 2 Can Reactivate Virus Production in Baboons but Is Contained by a CD8 T Cell Antiviral Response

Ist Teil von

• The Journal of infectious diseases, 1997-10, Vol.176 (4), p.948-959

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1997

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• An animal model was used to assess whether resistance to superinfection by human immunodeficiency virus (HIV) can exist in vivo. Asymptomatic baboons (Papio cynocephalus), previously infected with HIV-2, were first challenged with homologous virus (HIV-2UC2 or HIV-2UC14) and later with heterologous virus (HIV-2UC12). After both virus inoculations, either resistance to viral infection or a transient viremia was observed. The original virus was recovered in 3 baboons, suggesting that reactivation of a latent infection occurred on heterologous challenge and that HIV-2 superinfection is blocked by processes established during prior infection. Antibody titers measured by ELISA and virus neutralization remained at low levels. However, suppression of HIV-1 replication was observed with CD8 T cells and filtered cell culture supernatants. The soluble factor involved was not a β-chemokine. This resistance to HIV superinfection appears to be mediated at least in part by CD8 T cells that suppress virus production.