Nature (London), 1989-11, Vol.342 (6245), p.45-50
1989
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Details
- Autor(en) / Beteiligte
- Titel
- Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans
- Ist Teil von
- Nature (London), 1989-11, Vol.342 (6245), p.45-50
- Ort / Verlag
- London: Nature Publishing
- Erscheinungsjahr
- 1989
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The Caenorhabditis elegans gene unc-22 encodes a very large muscle protein, called twitchin, which consists of a protein kinase domain and several copies of two short motifs. The sequence of twitchin has unexpected similarities to the sequences of proteins of the immunoglobulin superfamily, cell adhesion molecules and vertebrate muscle proteins, including myosin light-chain kinase. These homologies, together with results from earlier genetic and molecular analyses, indicate that twitchin is involved in a novel mechanism of myosin regulation.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0028-0836eISSN: 1476-4687DOI: 10.1038/342045a0Titel-ID: cdi_proquest_miscellaneous_79298651
- Format
- –
- Schlagworte
- Amino Acid Sequence, Analytical, structural and metabolic biochemistry, Animals, Biological and medical sciences, Caenorhabditis - genetics, Caenorhabditis - metabolism, Caenorhabditis elegans, Caenorhabditis elegans Proteins, Calmodulin-Binding Proteins, Cellular biology, Enzymes and enzyme inhibitors, Fundamental and applied biological sciences. Psychology, Genes, Genetics, Helminth Proteins - genetics, Molecular Sequence Data, Muscle Proteins - genetics, myosin, Myosin-Light-Chain Kinase - genetics, Myosins - metabolism, Protein Kinases - genetics, Proteins, Restriction Mapping, Sequence Homology, Nucleic Acid, Transferases, twitchin