Details

Autor(en) / Beteiligte

• Miles, Anne Marie V.
• Markell, Mariana S.
• Daskalakis, Paula
• Sumrani, Nabil B.
• Hong, Joon
• Sommer, Bruce G.
• Friedman, Eli A.

Titel

Anemia following renal transplantation: erythropoietin response and iron deficiency

Ist Teil von

• Clinical transplantation, 1997-08, Vol.11 (4), p.313-315

Ort / Verlag

Oxford: Munksgaard International Publishers

Erscheinungsjahr

1997

Quelle

Wiley-Blackwell Full Collection

Beschreibungen/Notizen

• To define the etiology of anemia post‐renal transplantion, we assessed hematologic parameters and EPO levels in 38 anemic and 16 nonanemic control renal transplant recipients (RTRS) with varying degrees of allograft function at periods >3 months post‐transplantation. Significant differences between the two groups were found for serum creatinine (Cr) 291.7±26.5 vs. 203.3±26.5 μmol/l, p<0.01; iron 9.3±0.92 vs. 13.6±1.7 μmol/l, p<0.05; and ferritin 345.5±90.8 vs. 91.1±18.5 μg/l, p<0.01. Serum. EPO levels were inappropriately low in anemic patients with no significant correlation between EPO and Cr or hematocrit (Hct) levels. Serum iron was the only predictive factor for anemia on regression analysis (p<0.05). Ferritin levels did not correlate with serum iron or Hct, and may be falsely elevated in iron deficient RTRS. Iron deficiency, poor renal function and inappropriately low EPO levels are major contributors to the 12% of our outpatient renal transplant population who are anemic.