Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5329), p.1097-1100
1997
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- Autor(en) / Beteiligte
- Titel
- An NGF-TrkA-Mediated Retrograde Signal to Transcription Factor CREB in Sympathetic Neurons
- Ist Teil von
- Science (American Association for the Advancement of Science), 1997-08, Vol.277 (5329), p.1097-1100
- Ort / Verlag
- Washington, DC: American Society for the Advancement of Science
- Erscheinungsjahr
- 1997
- Quelle
- Science Online_科学在线
- Beschreibungen/Notizen
- Nerve growth factor (NGF) is a neurotrophic factor secreted by cells that are the targets of innervation of sympathetic and some sensory neurons. However, the mechanism by which the NGF signal is propagated from the axon terminal to the cell body, which can be more than 1 meter away, to influence biochemical events critical for growth and survival of neurons has remained unclear. An NGF-mediated signal transmitted from the terminals and distal axons of cultured rat sympathetic neurons to their nuclei regulated phosphorylation of the transcription factor CREB (cyclic adenosine monophosphate response element-binding protein). Internalization of NGF and its receptor tyrosine kinase TrkA, and their transport to the cell body, were required for transmission of this signal. The tyrosine kinase activity of TrkA was required to maintain it in an autophosphorylated state upon its arrival in the cell body and for propagation of the signal to CREB within neuronal nuclei. Thus, an NGF-TrkA complex is a messenger that delivers the NGF signal from axon terminals to cell bodies of sympathetic neurons.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 0036-8075eISSN: 1095-9203DOI: 10.1126/science.277.5329.1097Titel-ID: cdi_proquest_miscellaneous_79221652
- Format
- –
- Schlagworte
- Anatomy, Animals, Animals, Newborn, Axonal Transport, Axons, Axons - metabolism, Biological and medical sciences, Carbazoles - pharmacology, Cell lines, Cell Membrane - metabolism, Cells, Cells, Cultured, Cellular immunity, Cyclic adenosine monophosphate, Cyclic adenylic acid, Cyclic AMP Response Element-Binding Protein - metabolism, Fundamental and applied biological sciences. Psychology, Immunocytochemistry, Indole Alkaloids, Microspheres, Nerve growth factor, Nerve Growth Factors - metabolism, Nerve Growth Factors - pharmacology, Neurons, Neurons - metabolism, Neuroscience, Observation, PC12 cells, Peripheral nervous system. Autonomic nervous system. Neuromuscular transmission. Ganglionic transmission. Electric organ, Phosphorylation, Proto-Oncogene Proteins - antagonists & inhibitors, Proto-Oncogene Proteins - metabolism, Rats, Receptor Protein-Tyrosine Kinases - antagonists & inhibitors, Receptor Protein-Tyrosine Kinases - metabolism, Receptor, trkA, Receptors, Nerve Growth Factor - antagonists & inhibitors, Receptors, Nerve Growth Factor - metabolism, Signal Transduction, Signals, Superior Cervical Ganglion - cytology, Synapses, Vertebrates: nervous system and sense organs