Details

Autor(en) / Beteiligte

• Cheruvallath, V.K
• Riley, C.M
• Narayanan, S.R
• Lindenbaum, S
• Perrin, J.H

Titel

A quantitative circular dichroic investigation of the binding of the enantiomers of ibuprofen and naproxen to human serum albumin

Ist Teil von

• Journal of pharmaceutical and biomedical analysis, 1997-07, Vol.15 (11), p.1719-1724

Ort / Verlag

Amsterdam: Elsevier B.V

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• The binding constants for racemic, R and S naproxen and ibuprofen to human serum albumin have been determined by a circular dichroic technique. The ibuprofens and naproxens show no measurable extrinsic optical activity on interaction with the protein, and so the extrinsic Cotton effect shown following the diazepam–albumin interaction is used as a probe. The presence of the drugs reduce the amount of diazepam bound as shown by the reduced size of the induced ellipticity. The calculated primary binding constants show that the S form of both drugs bind to the albumin more tightly than the R form and that the racemic forms bind less tightly than either enantiomer.