Details

Autor(en) / Beteiligte

• Kato, Kimitoshi
• Murai, Ichiro
• Asai, Satoshi
• Komuro, Sachiko
• Matsuno, Yoshiaki
• Matsukawa, Yoshihiro
• Kurosaka, Hanzo
• Iwasaki, Ariyoshi
• Ishikawa, Koichi
• Arakawa, Yasuyuki

Titel

Central effect of melatonin against stress-induced gastric ulcers in rats

Ist Teil von

• Neuroreport, 1997-07, Vol.8 (9), p.2305-2309

Ort / Verlag

Hagerstown, MD: Lippincott-Raven Publishers

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• WE investigated the role of melatonin in the induction of gastric lesions induced by water immersion restraint stress or centrally administered thyrotropin-releasing hormone (TRH). Melatonin (0.1–1 ng) injected intracisternally (i.c.) 30 min prior to stress dose-dependently inhibited the induction of gastric lesions by water immersion restraint stress, while 100 μg/kg, i.p. failed to protect the gastric mucosa. Preadministration of melatonin (1 ng, i.c.) significantly reduced (83%) the severity of gastric lesions induced by a TRH analogue (500 ng, i.c.). Serum melatonin concentrations 30 min after administration of 1 ng melatonin i.c. did not differ from those of rats receiving i.c. vehicle. These results suggest that melatonin plays a protective, anti-stress, role in the gastric mucosa via a mechanism involving the central nervous system.