Details

Autor(en) / Beteiligte

• Shibata, Rir
• Maldarelli, Frank
• Siemon, Christine
• Matano, Tetsuro
• Parta, Mark
• Miller, Georgina
• Fredrickson, Torgny
• Martin, Malcolm A.

Titel

Infection and Pathogenicity of Chimeric Simian-Human Immunodeficiency Viruses in Macaques: Determinants of High Virus Loads and CD4 Cell Killing

Ist Teil von

• The Journal of infectious diseases, 1997-08, Vol.176 (2), p.362-373

Ort / Verlag

Chicago, IL: The University of Chicago Press

Erscheinungsjahr

1997

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• Chimeric simian-human immunodeficiency viruses (SHIVs) carrying envelope glycoproteins derived from a T cell-macrophage dual-tropic primary isolate (human immunodeficiency virus type 1 [HIV-1] strain DH12) were constructed. When inoculated into macaque monkeys, SHIVMD14 carrying simian immunodeficiency virus-derived nef established significantly higher virus loads than did SHIVMD1, which contains the HIV-1 nef gene. Three patterns of CD4 cell depletion were observed in infected monkeys: exponential and irreversible loss to undetectable levels within 10 weeks of infection; marked reduction during acute infection followed by partial recovery and stabilization (lasting from 10 weeks to > 1 year), with a later decline to undetectable levels in some animals; and a transient loss during acute infection. The induced immunodeficiency was accompanied by CD4 cell counts of < 50 cells/µL and was associated with Pneumocystis carinii pneumonia, cytomegalovirus meningoencephalitis, lymphoid depletion, and thymica trophy.