Details

Autor(en) / Beteiligte

• Dennison, Barbara A.
• Kikuchi, David A.
• Srinivasan, Sathanur B.
• Webber, Larry S.
• Berenson, Gerald S.

Titel

Parental history of cardiovascular disease as an indication for screening for lipoprotein abnormalities in children

Ist Teil von

• The Journal of pediatrics, 1989-08, Vol.115 (2), p.186-194

Ort / Verlag

New York, NY: Mosby, Inc

Erscheinungsjahr

1989

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• We studied the relationship between parental history of cardiovascular disease and risk for adverse lipid and lipoprotein levels in a total community study of 3313 children (ages 4 to 17 years, 63% white, 37% black). Older white children (11 to 17 years) with a parental history of heart attack or diabetes were 4.3 and 5.6 times, respectively, more likely to have high levels (>95th percentile) of serum total cholesterol than those without such a history (all p<0.05). White children with a parental history of heart attack or diabetes were twice as likely to have an elevated (≥95th percentile) low-density lipoprotein cholesterol (LDL-C) level than those without such a history (both p<0.05). In contrast, parental history of cardiovascular disease did not predict elevated levels of total cholesterol or LDL-C in black children. However, older black children with a parental history of heart attack, hypertension, or diabetes were 41/2 to 5 times more likely to have low levels (<5th percentile) of high-density lipoprotein cholesterol than those without such a history (all p<0.05). Only 40% of white children and 21% of black children with elevated LDL-C levels had a parental history of vascular disease. These findings raise questions about the current practice of screening only children with a family history of cardiovascular disease to identify those with elevated total cholesterol and LDL-C levels.