Details

Autor(en) / Beteiligte

• IKEMOTO, HIDEO
• WATANABE, KAZUYOSHI
• MORI, TAKESHI
• IGARI, JUN
• OGURI, TOYOKO
• KAWAGUCHI, HIDEAKI
• SHIMIZU, YOSHINORI
• MATSUMIYA, HIDEMI
• SAITO, AKIRA
• TERAI, TSUGIO
• INOUE, HIROSHI
• NAKADATE, TOSHIHIDE
• ITO, CHUICHI
• YOSIDA, TAKESI
• TANNO, YASUO
• OHNO, ISAO
• NISHIOKA, KIYO
• ARAKAWA, MASAAKI
• IGARASHI, KENICHI
• WADA, KOUICHI
• OKADA, MASAHIKO
• OZAKI, KYOKO
• AOKI, NOBUKI
• KITAMURA, NOBUKO
• SEKINE, OSAMU
• SUZUKI, YASUTOSHI
• MATSUDA, MASAFUMI
• TANIMOTO, HIROICHI
• NAKATA, KOUICHIRO
• NAKATANI, TATSUO
• INAGAWA, HIROKO
• KABE, JUNZABUROU
• KUDO, KOUICHIRO
• YAMAMOTO, YUMIKO
• ISHIHARA, TERUO
• OKADA, JUN
• KOBAYASHI, HIROYUKI
• KAWAI, SHIN
• TAKAYASU, SATOSHI
• TAKEDA, HIROAKI
• SHIMADA, KAORU
• YAMAGUCHI, KEIZO
• MATSUMOTO, TETSUYA
• IWATA, MORIHIRO
• KASHITANI, FUSAKO
• ITO, AKIRA
• SUMITOMO, MIDORI
• KAKU, MITSUO
• MATSUSHIMA, TOSHIHARU
• NIKI, YOSHIHITO
• SOEJIMA, RINZO
• ANDO, MASAYUKI
• YAMANE, NOBUHISA
• TOSAKA, MASAKAZU
• KOHNO, SHIGERU
• TANAKA, HIRONORI
• HIRAKATA, YOICHI
• MATSUDA, JUNICHI
• NASU, MASARU
• ITO, MORIO
• YAMAZAKI, TOURU
• NAKANO, TADAO
• SAITO, ATSUSHI
• KUSANO, NOBUCHIKA
• TOUYAMA, MASATO

Titel

SUSCEPTIBILITIES OF BACTERIA ISOLATED FROM PATIENTS WITH RESPIRATORY INFECTIOUS DISEASES TO ANTIBIOTICS (1995)

Ist Teil von

• The Japanese Journal of Antibiotics, 1997/05/25, Vol.50(5), pp.421-459

Ort / Verlag

Japan: Japan Antibiotics Research Association

Erscheinungsjahr

1997

Quelle

MEDLINE

Beschreibungen/Notizen

• The bacteria isolated from the patients with lower respiratory tract infections were collected by institutions located throughout Japan, since 1981. IKEMOTO et al. have been investigating susceptibilities of these isolates to various antibacterial agents and antibiotics, and characteristics of the patients and isolates from them each year. Results obtained from these investigations are discussed In 23 institutions around the entire Japan, 567 strains of presumably etiological bacteria were isolated mainly from the sputa of 459 patients with lower respiratory tract infections during the period from October 1995 to September 1996. MICs of various antibacterial agents and antibiotics were determined against 74 strains of Staphylococcus aureus, 82 strains of Streptococcus pneumoniae, 104 strains of Haemophilus influenzae, 85 strains of Pseudomonas aeruginosa (non-mucoid strains), 18 strains of Pseudomonas aeruginosa (mucoid strains), 52 strains of Moraxella subgenus Branham-ella catarrhalis, 25 strains of Klebsiella pneumoniae etc., and the drug sceptibilities of these strains were assessed except for those strains that died during ransportation. 1) S. aureus S. aureus strains for which MICs of oxacillin (MPIPC) were higher than 4μg/ml (methicillin-resistant S. aureus) accounted for 52.7%. Arbekacin (ABK) showed the most highest activity against S. aureus with MIC80, of 0.5μg/ml. Vancomycin (VCM) showed the next highest activity with MIC80, of 1μg/ml. These drugs showed the high activities against MRSA with MIC80s of 1μg/ml. 2) S. pneumoniae Most of drugs tested showed potent activities against S. pneumoniae. Imipenem (IPM) and panipenem (PAPM), carbapenems, showed the most potent activitiy with MIC80s of 0.063μg/ml. Cefotaxime (CTX), cefmenoxime (CMX) and cefpirome (CPR) of cephems showed the next most potent activities with MIC80s of 0.25μg/ml. Erythromycin (EM) and clindamycin (CLDM) showed low activities with MIC80s 128μg/ml or high. Among these strains, however, 48.8% and 65.9% of respective strains were quite toward sensitive these agents with MICs of 0.063μg/ml. 3) H. influenzae The activities of all drugs were potent against H. influenzae tested with all MICs at 4μg/ml or below. Cefotiam (CTM), CMX, cefditoren (CDTR) and ofloxacin (OFLX) showed the most potent activity with MIC90s of 0.063μg/ml. 4) P. aeruginosa (mucoid strains) IPM and tobramycin (TOB) showed the most potent activity against P. aeruginosa (mucoid strains) with MIC80s of 1μg/ml. Ceftazidime (CAZ), cefsulodin (CFS) and carumonam (CRMN) showed next potent activity, with MIC80s of 2μg/ml. The MIC80s of the other drugs ranged from 4μg/ml to 32μg/ml. May 1997 THE JAPANESE JOURNAL OF ANTIBIOTICS 50-5 459(39) 5) P. aeruginosa (non-mucoid strains) TOB and ciprofloxacin (CPFX) showed the most potent activities against P. aeruginosa (non-mucoid strains) with MIC80s of 1μg/ml. The MIC80 of ampicillin (ABPC) was 128μg/ml in 1994, it was 16μg/ml in 1995. 6) K. pneumoniae All drugs except ABPC were active against K. pneumoniae. CPR and CRMN showed the most potent activities against K. pneumoniae with MIC80s of 0.063μg/ml. The MIC80s of the other drugs ranged from 0.125μg/ml to 2μg/ml. 7) M.(B.) catarrhalis Against M.(B.) catarrhalis, all the drugs showed good activities with MIC80s at 4μg/ml or below. And MICs of all strains were 8μg/ml or below. IPM, OFLX and minocycline (MINO) showed the most potent activity with MIC80s of 0.063μg/ml. Also, we investigated year to year changes in the characteristics of patients, their respiratory infectious diseases, and the etiology. Patients' backgrounds were examine for 567 isolates from 459 cases. The examination of age distribution found that the proportion of patients with ages over 60 years was 66.3% of all the patients showing a slight increase over that in 1994. Proportions of different diseases were as follows.