Details

Autor(en) / Beteiligte

• Dotzlaq, Helmut
• Leygue, Etienne
• Watson, Peter H
• Murphy, Leigh C

Titel

Expression of Estrogen Receptor-β in Human Breast Tumors

Ist Teil von

• The journal of clinical endocrinology and metabolism, 1997-07, Vol.82 (7), p.2371-2374

Ort / Verlag

Bethesda, MD: Endocrine Society

Erscheinungsjahr

1997

Link zum Volltext

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• The expression of a recently described novel estrogen receptor, ER-β, was detected in several human breast tumor biopsy samples and several human breast epithelial cell lines using reverse transcription and polymerase chain reaction (RT-PCR) analysis. Cloning and sequencing of the PCR product from a breast tumor confirmed the identity of the sequence with that of the ER-β mRNA previously reported in human testis. The expression of ER-β was not correlated with that of ER-α, and both ER-α positive and ER-α negative cell lines expressed ER-β mRNA. However, some breast tumors and some cell lines coexpress ER-β and ER-α mRNA. Our data support a possible role for ER-β in human breast cancer.