Details

Autor(en) / Beteiligte

• Iwasa, Fuyuki
• Furuya, Mayumi
• Hayashi, Yujiro
• Ohnuma, Norio

Titel

Differential Stimulation of Rat Lung Particulate Guanylate Cyclase Activity by Atrial Natriuretic Peptide and Sodium Nitroprusside

Ist Teil von

• Journal of biochemistry (Tokyo), 1989-05, Vol.105 (5), p.697-699

Ort / Verlag

Oxford: Oxford University Press

Erscheinungsjahr

1989

Quelle

MEDLINE

Beschreibungen/Notizen

• The effects of α-rat atrial natriuretic peptide (α-rANP) and sodium nitroprusside on the activity of rat lung particulate guanylate cyclase were examined. The particulate guanylate cyclase in partially purified rat lung membranes was stimulated by both α-rANP and nitroprusside. The effects of α-rANP and nitroprusside were, however, not additive. Diamide and N-ethylmaleimide almost completely abolished the nitroprusside-mediated stimulation, while they had only moderate effects on the α-rANP-mediated stimulation of the enzyme activity. ATP potentiated the enzyme stimulation by α-rANP, whereas it had no effect on the nitroprusside-mediated stimulation. These findings suggest that the stimulation of lung particulate guanylate cyclase activity by α-rANP and nitroprusside is mediated by different mechanisms.