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Further study on the changes in the concentration of prolactin-binding sites in different organs of Xenopus laevis male and female, kept under dry conditions and then returned to water (their natural habitat)
Ist Teil von
General and comparative endocrinology, 1989-06, Vol.74 (3), p.411-417
Ort / Verlag
San Diego, CA: Elsevier Inc
Erscheinungsjahr
1989
Link zum Volltext
Quelle
Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)
Beschreibungen/Notizen
The binding of
125I-labeled ovine prolactin (
125I-oPRL) to membranes from the kidney and liver of
Xenopus laevis male and female specimens (Experiment I) and from the kidney, epidermis, and liver of female specimens (Experiment II) (1) kept in an aquatic environment, (2) exposed for 2 weeks to dehydrating conditions, and (3) then placed back into their aquaria after exposure to dehydrating conditions (Experiment II) was studied. No significant sex differences in PRL binding to kidney, epidermis, and liver were found. A highly significant drop in PRL specific binding to the membranes from the kidney and epidermis is brought about in the specimens from both sexes exposed to dehydrating conditions. The results obtained by MgCl
2 treatment
in vitro of the membranes under study for an estimation of total PRL receptor concentrations seem to point to an actual decrease in PRL specific binding sites. The values of PRL specific binding to the membranes from the liver are not affected by dehydration of the animals (Experiment I and II) or their subsequent rehydration (Experiment II). In rehydrated females (Experiment II), PRL binding values were closely related to those recorded in females permanently maintained in water (controls).