Details

Autor(en) / Beteiligte

• Murayama, Y
• Amano, A
• Mukai, R
• Shibata, H
• Matsunaga, S
• Takahashi, H
• Yoshikawa, Y
• Hayami, M
• Noguchi, A

Titel

CD4 and CD8 expressions in African green monkey helper T lymphocytes: implication for resistance to SIV infection

Ist Teil von

• International immunology, 1997-06, Vol.9 (6), p.843-851

Ort / Verlag

England: Oxford Publishing Limited (England)

Erscheinungsjahr

1997

Quelle

Oxford Journals 2020 Medicine

Beschreibungen/Notizen

• We found that most peripheral CD4 cells co-express a low density of CD8 alpha antigen in African green monkeys (AGM). Further, the cell surface expression of CD4 and the expression of CD4 mRNA underwent a decrease when purified CD4CD8low cells were cultured with mitogen and IL-2. These observations suggest that AGM CD4 cells are subject to loss of CD4 expression after lymphocyte activation. Part of the peripheral CD8 fraction exhibited a significant helper activity which suggested the phenotypic conversion in helper T cells from CD4+ to CD4- in vivo. Simian immunodeficiency virus (SIV) grew well in CD4 panning cells following SIV infection. In contrast, CD4CD8low cells were resistant to SIV infection after their conversion to CD4- cells.