Nature structural biology, 1997-06, Vol.4 (6), p.435-438
1997
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Details
- Autor(en) / Beteiligte
- Titel
- X-ray structure of glial cell-derived neurotrophic factor at 1.9 Å resolution and implications for receptor binding
- Ist Teil von
- Nature structural biology, 1997-06, Vol.4 (6), p.435-438
- Ort / Verlag
- United States
- Erscheinungsjahr
- 1997
- Quelle
- MEDLINE
- Beschreibungen/Notizen
- The crystal structure of glial cell-derived neurotrophic factor (GDNF) reveals two independent copies of the dimer that differ significantly through a hinge bending at the central, disulphide-rich region. GDNF is compared with other members of the TGF-beta family, and potential receptor binding surfaces are identified.
- Sprache
- Englisch
- Identifikatoren
- ISSN: 1072-8368eISSN: 2331-365XDOI: 10.1038/nsb0697-435Titel-ID: cdi_proquest_miscellaneous_79073691
- Format
- –
- Schlagworte
- Amino Acid Sequence, Binding Sites, Bone Morphogenetic Protein 7, Bone Morphogenetic Proteins - chemistry, Crystallography, X-Ray, Dimerization, Drosophila Proteins, Glial Cell Line-Derived Neurotrophic Factor, Glial Cell Line-Derived Neurotrophic Factor Receptors, Models, Molecular, Molecular Sequence Data, Nerve Growth Factors - chemistry, Nerve Tissue Proteins - chemistry, Nerve Tissue Proteins - metabolism, Neurturin, Protein Conformation, Proto-Oncogene Proteins - chemistry, Proto-Oncogene Proteins - metabolism, Proto-Oncogene Proteins c-ret, Receptor Protein-Tyrosine Kinases - chemistry, Receptor Protein-Tyrosine Kinases - metabolism, Sequence Homology, Amino Acid, Transforming Growth Factor beta - chemistry, Transforming Growth Factor beta - metabolism