Details

Autor(en) / Beteiligte

• Stenger, Steffen
• Mazzaccaro, Richard J.
• Uyemura, Koichi
• Cho, Sungae
• Barnes, Peter F.
• Rosat, Jean-Pierre
• Sette, Alessandro
• Brenner, Michael B.
• Porcelli, Steven A.
• Bloom, Barry R.
• Modlin, Robert L.

Titel

Differential Effects of Cytolytic T Cell Subsets on Intracellular Infection

Ist Teil von

• Science (American Association for the Advancement of Science), 1997-06, Vol.276 (5319), p.1684-1687

Ort / Verlag

Washington, DC: American Society for the Advancement of Science

Erscheinungsjahr

1997

Quelle

Science magazine suite

Beschreibungen/Notizen

• In analyzing mechanisms of protection against intracellular infections, a series of human CD1-restricted T cell lines of two distinct phenotypes were derived. Both CD4$^-$CD8$^-$ (double-negative) T cells and CD8$^+$ T cells efficiently lysed macrophages infected with Mycobacterium tuberculosis. The cytotoxicity of CD4$^-$CD8$^-$ T cells was mediated by Fas-FasL interaction and had no effect on the viability of the mycobacteria. The CD8$^+$ T cells lysed infected macrophages by a Fas-independent, granule-dependent mechanism that resulted in killing of bacteria. These data indicate that two phenotypically distinct subsets of human cytolytic T lymphocytes use different mechanisms to kill infected cells and contribute in different ways to host defense against intracellular infection.