Details

Autor(en) / Beteiligte

• Pupita, Giuseppe
• Kaski, Juan Carlos
• Galassi, Alfredo R.
• Vejar, Margarita
• Crea, Filippo
• Maseri, Attilio

Titel

Long-term variability of angina pectoris and electrocardiographic signs of ischemia in syndrome X

Ist Teil von

• The American journal of cardiology, 1989-07, Vol.64 (3), p.139-143

Ort / Verlag

New York, NY: Elsevier Inc

Erscheinungsjahr

1989

Quelle

Elsevier Journal Backfiles on ScienceDirect (DFG Nationallizenzen)

Beschreibungen/Notizen

• The long-term course of angina and the electrocardiographic signs of ischemia were assessed in 13 patients (10 women and 3 men, mean age 49 ± 6 years) with typical angina pectoris, positive exercise tests, no evidence of coronary spasm and angiographically normal coronary arteries (syndrome X). Clinical and electrocardiographic parameters as well as results of exercise testing and 24-hour electrocardiographic monitoring were assessed at presentation and after a mean follow-up of 6.3 years (range 3 to 9). Mean number of anginal episodes and nitroglycerin consumption per week were similar at presentation and at the last follow-up. Furthermore, no significant difference was noted in heart rate-systolic blood pressure product at 0.1 mV of ST-segment depression (20,363 ± 5,747 vs 21,649 ± 5,687 beats/min × mm Hg), at angina (19,223 ± 5,680 vs 20,126 ± 6,023 beats/min × mm Hg) and at peak exercise (22,057 ± 5,669 vs 22,868 ± 6,122 beats/min × mm Hg). Time to 0.1 mV of ST-segment depression, to angina and to peak exercise was also similar (595 ± 163 vs 631 ± 184 s, 524 ± 156 vs 571 ± 168 s and 671 ± 168 vs 718 ± 186 s, respectively). The number of episodes of ST-segment depression ≥0.1 mV during etectrocardiographic monitoring was similar at presentation and follow-up (31 vs 25) as was the proportion of painful episodes (39 vs 36%). None of the patients developed major coronary events or cardiomyopathy during follow-up. Thus, although patients with syndrome X seem to have a benign prognosis, angina and electrocardiographic signs of ischemia tend to persist almost unchanged during long periods, adversely affecting lifestyle in a sizable proportion of patients.