Details

Autor(en) / Beteiligte

• Lackner, Andrew A
• Marx, Preston A
• Lerche, Nicholas W
• Gardner, Murray B
• Kluge, John D
• Spinner, Abigail
• Kwang, Hwei-Sing
• Lowenstine, Linda J

Titel

Asymptomatic Infection of the Central Nervous System by the Macaque Immunosuppressive Type D Retrovirus, SRV-1

Ist Teil von

• Journal of general virology, 1989-07, Vol.70 (7), p.1641-1651

Ort / Verlag

Reading: Soc General Microbiol

Erscheinungsjahr

1989

Link zum Volltext

Quelle

MEDLINE

Beschreibungen/Notizen

• 1 California Primate Research Center and 2 Department of Veterinary Pathology 3 Department of Veterinary Medicine and 4 Medical Pathology, University of California, Davis, California 95616, U.S.A. The aetiological agent of spontaneously occurring simian acquired immune deficiency syndrome (SAIDS) in rhesus monkeys ( Macaca mulatta ) at the California Primate Research Center is a type D retrovirus designated SAIDS retrovirus serotype 1 (SRV-1). SRV-1 DNA and RNA have previously been detected in the brains of rhesus monkeys with SAIDS in the absence of viral antigen or neuropathological lesions. In this study we further define the relationship between SRV-1 and the central nervous system (CNS) in rhesus monkeys by examining the CNS for infectious SRV-1, viral antigen and anti-SRV-1 antibodies. In addition, cerebrospinal fluid (CSF) was assayed for alterations in IgG and albumin levels, IgG/albumin ratios and cell count in comparison to uninfected control animals. No differences in CSF parameters were detected between infected and uninfected animals except for the presence of infectious SRV-1 which was isolated from the CSF from 13 out of 19 (68%) viraemic rhesus monkeys. The probable source of this virus was the choroid plexus, where approximately 1 in 1000 surface epithelial cells were found to contain viral antigen by immunohistochemistry. Antibodies against SRV-1 were not detected in the CSF even when present in the serum. Neither infectious virus nor viral antigen were found in the brain parenchyma of any animal examined. Thus infection of the CNS by SRV-1 appears to be subclinical without an intrathecal immune response. This may be related to the apparent restriction of productive infection in the CNS to cells of the choroid plexus. Keywords: type D retrovirus, central nervous system, macaque Present address: Department of Medicine, University of California, San Diego, California 92037, U.S.A. Received 3 January 1989; accepted 22 February 1989.