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Laterality in the Histological Effects of Injections of Amyloid-β 25-35 into the Amygdala of Young Fischer Rats
Ist Teil von
Journal of neuropathology and experimental neurology, 1997-06, Vol.56 (6), p.714-725
Ort / Verlag
Hagerstown, MD: American Association of Neuropathologists, Inc
Erscheinungsjahr
1997
Link zum Volltext
Quelle
Electronic Journals Library
Beschreibungen/Notizen
We have observed that single amyloid-β 25-35 (Aβ) injections (5.0 nmol) into the right amygdala of rats produce progressive cytoskeletal and astrogliotic reactions not only within the amygdala, but also in distal brain regions that project to the amygdala. To determine if these effects are potentiated by bilateral injections, we injected Aβ (5.0 nmol) into the left and right amygdala of young male Fischer rats. Animals were sacrificed 32 days postoperatively. Bilateral infusions of Aβ induced significant neuronal shrinkage, tau-2 neuronal staining, and reactive astrocytosis within the right amygdala and/or hippocampus, compared with vehicle-treated rats. Surprisingly, the same brain regions within the left hemisphere were significantly less affected even though no differences were observed between the left and right amygdala in the size of Congored-positive Aβ deposits. Unilateral injections of Aβ into the left amygdala led to significant histological changes in the right amygdala and hippocampus, but not in the same brain regions within the left hemisphere. These results suggest a laterality in the histopathological effects of Aβ in male Fischer rats. Identification of the cause for the lateralized effect of Aβ may prove valuable for understanding the etiology of Alzheimer disease and provide possible therapeutic strategies designed to slow the progression of the disease.